The Role of Osteopontin in Bone Resorption

Noengki Prameswari*) , Bambang Sucahyo*) , Rima Parwatisari **)

*)Orthodontia Department, **) Oral Biology Department

School of Dentistry, Hang Tuah University.

Gadung st 1, Dr Ramelan Naval Hospital Complex, Surabaya, Indonesia

Abstract

Osteopontin is a phosphorylated acidic glycoprotein that has been implicated in a number of physiological and pathological events, including it is required for efficient bone resorption. This cytokine mediates important cell matrix and cell-cell interaction. In vitro experiment, osteopontin can promote attachment of cells and stimulate signaling events in osteoclast. The aim of this this review is to explaine the role of osteopontin in osteoclast connected with bone resorption. Osteopontin stimulated CD44 expression on the osteoclast surface and it may promote osteoclast binding to resorptive sites by interacting with αvβ3 integrin receptor on osteoclast. The role of osteopontin in bone resorption is apparently more pronounced under circumstances of accelerated such as bone loss. In orthodontic tooth movement, increasing secretion osteopontin in early phase implies cellular reaction in bone resorption as a result application of light and intermittent forces.

Keyword : Osteopontin, Orthodontic tooth movement

Karya ilmiah ini dipresentasikan pada ceramah international Dental Congress the Mekong River Region di Bangkok, Thailand pada  7-10 Juni 2004

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Hyperbaric Oxygenation as a supportive therapy in Chronic Osteomyelitis of the Jaw

Noengki Prameswari ¹, Fanny M. Laihad ²

Bagian Ilmu Faal ¹, Bagian Bedah Mulut ²

Fakultas Kedokteran Gigi Univ. Hang Tuah Jl. Gadung no 1 Kompl RSAL Timur Surabaya

ABSTRACT

Chronic osteomyelitis of the jaw is usually due to untreated odontogenic infection, postextraction complications, and untreated or poorly managed mandibular fracture. A hypoxic condition shown on chronic osteomyelitis caused by oxygen consumption by microorganisms and inflammatory cells, and interferenced by local perfusion due to tissue edema. Hyperbaric oxygenation as a supportive therapy based on its application in the stimulation of tissue repair. Hyperbaric oxygenation raised tissue oxygen tension, enhances the leukocyte killing mechanisms, osteogenesis / neovascularization, and osteoclastic activity. The research was done during 1998-2000 in Dental Clinic of Dr. Ramelan Hospital. A regimen of hyperbaric oxygenation consisting of 100 % oxygen; 2,4 atmosphere pressure, one dive (90 minutes) per day, six dive per week was used in 10 patients to evaluate the effect of hyperbaric oxyegenation as a supportif therapy beside surgery and antibiotics to recovery duration.

Keyword : Chronic Osteomyelitis, Hyperbaric Oxygenation, Supportive therapy

Karya ilmiah ini dipublikasikan dalam ceramah internasional  5th Scientific Congress of The Federation of Asian-Oceanian Physiological Societies (FAOPS) di KualaLumpur 23-26 September 2002


FAOPS is the Federation of Asian and Oceanian Physiological Societies, and comprises the following participating Societies: Australia, China, India, Israel, Iran, Japan, Korea, Malaysia, China-Taipei, New Zealand, Philipines, Thailand, United Arab Emirates, Indonesia, Myanmar, Pakistan, Srilanka, and Vietnam

FAOPS Objectives: The purposes of the Federation are exclusively scientific, educational, literary, and no other, and in furtherance of only those purposes, the particular business and objectives of the Federation are;

1. to encourage the advancement of the physiological sciences
2. to facilitate the exchange and dissemination of knowledge in the field of physiological sciences and related fields
3. to foster and encourage research in the field of physiological sciences in Asia and Oceania
4. to promote the Congress of the Federation of the Asian and Oceanian Physiological Societies (FAOPS Congress
5. to promote such other measures as will contribute to the development of physiological sciences in Asia and Oceania.

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